This study evaluated the growth, yield, and water use of four lettuce cultivars (Lactuca sativa L. cv. ‘Green Forest’ (GF), ‘New Red Fire’ (NRF), ‘Paris Island’ (PI), and ‘Rouxai’ (R)) cultivated in three different hydroponic system types: Deep-Water Culture (DWC), Nutrient Film Technique (NFT), and Vertical System (VS). Trials were conducted across three seasons (S1: Oct–Nov 2023; S2: Mar–Apr 2024; S3: Apr–May 2024) in a high tunnel at the Texas A