Research into the health-promoting properties of dietary phenolics has highlighted phenolic-rich foods as a promising strategy for the preventive management of health and wellness. Building on this rationale, the present study focused on alliums, which have held a prominent place in traditional medicine for their therapeutic benefits since ancient times. Specifically, this research evaluated onion cultivars (Red Bull, Hamilton, Gunnison, and White Cap) for their total soluble phenolics and associated antioxidant and anti-hyperglycemic activity in-vitro. Two types of extracts were prepared: one from fresh samples to simulate raw consumption, and another from cooked samples. The total soluble phenolics (TSP) content was quantified using the Folin-Ciocalteu reducing assay. Antioxidant capacity was evaluated using DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS (2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging assays. The anti-hyperglycemic potential was assessed by measuring the percentage inhibition of α-amylase and α-glucosidase enzyme. A significant difference (p
